diff --git a/cores/arduino/HardwareSerial.cpp b/cores/arduino/HardwareSerial.cpp
index 1c89de7f61..11cf90a7b1 100644
--- a/cores/arduino/HardwareSerial.cpp
+++ b/cores/arduino/HardwareSerial.cpp
@@ -446,7 +446,7 @@ void HardwareSerial::begin(unsigned long baud, byte config)
       break;
   }
 
-  uart_init(&_serial, (uint32_t)baud, databits, parity, stopbits);
+  uart_init(&_serial, (uint32_t)baud, databits, parity, stopbits, _rx_invert, _tx_invert, _data_invert);
   enableHalfDuplexRx();
   uart_attach_rx_callback(&_serial, _rx_complete_irq);
 }
@@ -668,4 +668,19 @@ void HardwareSerial::enableHalfDuplexRx(void)
   }
 }
 
+void HardwareSerial::setRxInvert(void)
+{
+  _rx_invert = true;
+}
+
+void HardwareSerial::setTxInvert(void)
+{
+  _tx_invert = true;
+}
+
+void HardwareSerial::setDataInvert(void)
+{
+  _data_invert = true;
+}
+
 #endif // HAL_UART_MODULE_ENABLED && !HAL_UART_MODULE_ONLY
diff --git a/cores/arduino/HardwareSerial.h b/cores/arduino/HardwareSerial.h
index f8a2884de0..3ed29a873d 100644
--- a/cores/arduino/HardwareSerial.h
+++ b/cores/arduino/HardwareSerial.h
@@ -95,6 +95,9 @@ class HardwareSerial : public Stream {
   protected:
     // Has any byte been written to the UART since begin()
     bool _written;
+    bool _rx_invert;
+    bool _tx_invert;
+    bool _data_invert;
 
     // Don't put any members after these buffers, since only the first
     // 32 bytes of this struct can be accessed quickly using the ldd
@@ -165,6 +168,12 @@ class HardwareSerial : public Stream {
     bool isHalfDuplex(void) const;
     void enableHalfDuplexRx(void);
 
+    // Enable HW Rx/Tx/data inversion
+    // This needs to be done before the call to begin()
+    void setRxInvert(void);
+    void setTxInvert(void);
+    void setDataInvert(void);
+
     friend class STM32LowPower;
 
     // Interrupt handlers
diff --git a/keywords.txt b/keywords.txt
index a4a284e59a..5ddcab36dd 100644
--- a/keywords.txt
+++ b/keywords.txt
@@ -274,6 +274,9 @@ HALF_DUPLEX_ENABLED	LITERAL1
 setHalfDuplex	KEYWORD2
 isHalfDuplex	KEYWORD2
 enableHalfDuplexRx	KEYWORD2
+setRxInvert	KEYWORD2
+setTxInvert	KEYWORD2
+setDataInvert	KEYWORD2
 Serial4	KEYWORD1
 Serial5 KEYWORD1
 Serial6 KEYWORD1
diff --git a/libraries/SrcWrapper/inc/uart.h b/libraries/SrcWrapper/inc/uart.h
index a6c41390e7..7f99d498e7 100644
--- a/libraries/SrcWrapper/inc/uart.h
+++ b/libraries/SrcWrapper/inc/uart.h
@@ -38,6 +38,7 @@
 #define __UART_H
 
 /* Includes ------------------------------------------------------------------*/
+#include <stdbool.h>
 #include "stm32_def.h"
 #include "PinNames.h"
 
@@ -254,7 +255,7 @@ struct serial_s {
 
 /* Exported macro ------------------------------------------------------------*/
 /* Exported functions ------------------------------------------------------- */
-void uart_init(serial_t *obj, uint32_t baudrate, uint32_t databits, uint32_t parity, uint32_t stopbits);
+void uart_init(serial_t *obj, uint32_t baudrate, uint32_t databits, uint32_t parity, uint32_t stopbits, bool rx_invert, bool tx_invert, bool data_invert);
 void uart_deinit(serial_t *obj);
 #if defined(HAL_PWR_MODULE_ENABLED) && (defined(UART_IT_WUF) || defined(LPUART1_BASE))
 void uart_config_lowpower(serial_t *obj);
diff --git a/libraries/SrcWrapper/src/stm32/uart.c b/libraries/SrcWrapper/src/stm32/uart.c
index 04ccb2c820..4aaa3f0e2e 100644
--- a/libraries/SrcWrapper/src/stm32/uart.c
+++ b/libraries/SrcWrapper/src/stm32/uart.c
@@ -115,7 +115,7 @@ serial_t *get_serial_obj(UART_HandleTypeDef *huart)
   * @param  obj : pointer to serial_t structure
   * @retval None
   */
-void uart_init(serial_t *obj, uint32_t baudrate, uint32_t databits, uint32_t parity, uint32_t stopbits)
+void uart_init(serial_t *obj, uint32_t baudrate, uint32_t databits, uint32_t parity, uint32_t stopbits, bool rx_invert, bool tx_invert, bool data_invert)
 {
   if (obj == NULL) {
     return;
@@ -407,11 +407,31 @@ void uart_init(serial_t *obj, uint32_t baudrate, uint32_t databits, uint32_t par
   huart->Init.Mode         = UART_MODE_TX_RX;
   huart->Init.HwFlowCtl    = flow_control;
   huart->Init.OverSampling = UART_OVERSAMPLING_16;
+#if defined(UART_ADVFEATURE_NO_INIT)
+  // Default value
+  huart->AdvancedInit.AdvFeatureInit = UART_ADVFEATURE_NO_INIT;
 #if defined(UART_ADVFEATURE_SWAP_INIT)
-  huart->AdvancedInit.AdvFeatureInit = UART_ADVFEATURE_SWAP_INIT;
+  huart->AdvancedInit.AdvFeatureInit |= UART_ADVFEATURE_SWAP_INIT;
   huart->AdvancedInit.Swap = pin_swap;
-#elif defined(UART_ADVFEATURE_NO_INIT)
-  huart->AdvancedInit.AdvFeatureInit = UART_ADVFEATURE_NO_INIT;
+#endif
+#if defined(UART_ADVFEATURE_RXINVERT_INIT)
+  if (rx_invert) {
+    huart->AdvancedInit.AdvFeatureInit |= UART_ADVFEATURE_RXINVERT_INIT;
+    huart->AdvancedInit.RxPinLevelInvert = UART_ADVFEATURE_RXINV_ENABLE;
+  }
+#endif
+#if defined(UART_ADVFEATURE_TXINVERT_INIT)
+  if (tx_invert) {
+    huart->AdvancedInit.AdvFeatureInit |= UART_ADVFEATURE_TXINVERT_INIT;
+    huart->AdvancedInit.TxPinLevelInvert = UART_ADVFEATURE_TXINV_ENABLE;
+  }
+#endif
+#if defined(UART_ADVFEATURE_DATAINVERT_INIT)
+  if (data_invert) {
+    huart->AdvancedInit.AdvFeatureInit |= UART_ADVFEATURE_DATAINVERT_INIT;
+    huart->AdvancedInit.DataInvert = UART_ADVFEATURE_DATAINV_ENABLE;
+  }
+#endif
 #endif
 #ifdef UART_ONE_BIT_SAMPLE_DISABLE
   huart->Init.OneBitSampling = UART_ONE_BIT_SAMPLE_DISABLE;
@@ -812,7 +832,7 @@ void uart_debug_init(void)
     serial_debug.pin_tx = pinmap_pin(DEBUG_UART, PinMap_UART_TX);
 #endif
     /* serial_debug.pin_rx set by default to NC to configure in half duplex mode */
-    uart_init(&serial_debug, DEBUG_UART_BAUDRATE, UART_WORDLENGTH_8B, UART_PARITY_NONE, UART_STOPBITS_1);
+    uart_init(&serial_debug, DEBUG_UART_BAUDRATE, UART_WORDLENGTH_8B, UART_PARITY_NONE, UART_STOPBITS_1, false, false, false);
   }
 }